St. John's Wort for Depression

Effectiveness

St. John's wort rates as a likely effective treatment for depression. There are more than 10 studies which confirm its effectiveness.
 

Dosage

People in studies most commonly take 300 mg three times daily for up to 6 weeks.
 

Safety

St. John's wort rates as likely safe when used orally. There are more than 10 studies which confirm its safety.
 

Adverse Reactions

St. John's wort is usually well tolerated when used in typical doses.
 
Side effects can include:
  • insomnia
  • vivid dreams
  • restlessness
  • anxiety
  • agitation
  • irritability
  • gastrointestinal (GI) discomfort
  • diarrhea
  • fatigue
  • dry mouth
  • dizziness
  • headache
 
St. John's wort can also cause skin rash, paresthesia, and hypoglycemia.
 
Decrease insomnia by decreasing the dose or taking St. John's wort in the morning.
 
People treated with St. John's wort had side effects like the placebo. Side effects are less than conventional antidepressants.
 

Interactions

Alprazolam (Xanax). Do not take this combination.
Contraceptive drugs.  Do not take this combination.
Cyclosporine (Neoral, Sandimmune).  Do not take this combination.
Digoxin (Lanoxin).  Do not take this combination.
Docetaxel (Taxotere).  Do not take this combination.
Imatinib (Gleevec).  Do not take this combination.
Irinotecan (Camptosar).  Do not take this combination.
Ketamine (Ketalar).  Do not take this combination.
Mephenytoin (Mesantoin).  Do not take this combination.
Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs).  Do not take this combination.
Omeprazole (Prilosec).  Do not take this combination.
Oxycodone (Oxycontin).  Do not take this combination.
P-glycoprotein Substrates.  Do not take this combination.
Phenobarbital (Luminal).  Do not take this combination.
Phenprocoumon (Marcoumar, Others).  Do not take this combination.
Phenytoin (Dilantin).  Do not take this combination.
Protease Inhibitors (PIs).  Do not take this combination.
Tacrolimus (Prograf).  Do not take this combination.
Warfarin (Coumadin).  Do not take this combination.

Aminolevulinic acid.  Be cautious with this combination.
Barbiturates. Be cautious with this combination.
Bupropion (Wellbutrin).  Be cautious with this combination.
Clopidogrel (Plavix).  Be cautious with this combination.
Clozapine (Clozaril).  Be cautious with this combination.